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faculty

Laisheng Chou, DMD, PhD Professor and Director, Division of Oral Medicine; Professor of Biomaterials; Director, Oral AIDS Clinic lchou@bu.edu

education

• DMD, Shanghai No.2 Medical University (China)
• Certificate in Oral Pathology, University of California, San Francisco
• Certificate in Oral Medicine, University of California, San Francisco
• PhD in Oral Biology, University of British Columbia

research interests

Molecular biocompatibility of implant materials. Hydroxyapatite (HA) and bioactive glass materials are commonly used in medical and dental implants. However, the mechanisms by which implant material surface chemistry and topography initiate the biological tissue response, and the molecular nature the tissue response still remain largely unknown. This study aims to establish the in vitro and in vivo molecular profiles of osteogenic activities as a function of biomaterial surface chemistry and topography. The expected profile will be used as a biological guide for: (1) the selection of optimal material surface chemistry and topography for controlled cell attachment and bone formation, and (2) the development of novel osteoinductive coating systems for dental and medical implant devices.

Engineered bone regeneration with biomimetic scaffolds. Over one million surgical operations annually in this country involve bone repair. An existing challenge in bone tissue engineering is to develop scaffolds which have programmed osteogenic bioactivity and biodegradation. The study has been carried out in this field is based on the hypothesis that the material chemistry and three-dimensional geometry of tissue engineering scaffolds can be manipulated under the guidance of biological parameters, resulting in scaffold-controlled tissue reactions favorable to bone regeneration. The long-term goal is to develop a novel approach to biomimetic scaffolds with ordered microarchitectures and biofunctional ingredients, as well as anatomically accurate macrostructure for clinical treatment of orofacial and orthopedic bone defects.

HIV-1 infection in oral mucosal Langerhans cells.

representative publications

Anhoury P, Nathanson D, Hughes CV, Socransky S, Feres M, Chou LL. Microbial profile on metallic and ceramic bracket materials.Angle Orthod. 2002 Aug;72(4):338-43.

L. Chou, S. Al-Bazie, D. Cottrell, R. Giodano, D. Nathanson: Atomic and molecular mechanisms underlying the osteogenic effects of bioglass materials. Bioceramics. 11:265-268.

S. Al-Bazie, D. Cottrell, D. Nathanson, L. Chou: In vivo study of the effects of Bioglass and HA bone synthetic grafts materials on the induction of osteocalcin and alkaline phosphtase. The Journal of Oral and Maxillofacial Surgery. 56:(8) 91-92.

L. Chou: Gold chloride enhancement in detection of Langerhans cells. Journal of Immunological Methods. (in press)

L. Chou, B. Marek, W. R. Wagner: Effects of hydroxylapatite coating crystallinity on biosolubility, cell attachment efficiency and proliferation in vitro. Biomaterials. (in press)

L. Chou, J. Firth, D. Nathanson, C. Oakley, V. Uitto and D. Brunette: Compensated translocation of fibronectin mRNA by substratum topography in microtubules- or actin filaments-depleted human fibroblasts. Nature. (submitted)

L. Chou, F. Boustany, D. Nathanson, J. Epstein, S. Cassol: G->A hypermutation in env loop V2 region of HIV-1 gene in oral hairy leukoplakia. Oral Surgery, Oral Medicine and Oral Pathology. (submitted)

L. Chou, D. Nathanson: Molecular biocompatibility of implant materials, Journal of Oral Implantology. (submitted)

L. Chou, J. Firth, Dan Nathanson, V. Uitto, and D, Brunette: Effect of titanium on transcriptional and post-transcriptional regulation of fibronectin in human fibroblasts. Journal of Biomedical Materials Research. 31:209-217, 1996.

S. Borland SW. Wu BM. Giordano RA. Computer-derived microstructure by 3D Printing: Bio- and Structural Materials. Proceedings of the SFF Symposium, 181-190 1994

L. Chou, J. Firth, V. Uitto and D. Brunette: Surface composition and topography of titanium on 72 kDa gelatinase gene expression and secretion. Journal of Biomedical Materials Research. 39:437-445, 1998.

D. Nathanson, P. Lertpitayakun, M. Lamkin, M. Edalatpour, L. Chou. In vitro elution of leachable components from dental sealants. Journal of American Dental Association 128:1517-1523, 1997.

L. Chou, J. Firth, V. Uitto and D. Brunette: Effect of surface topography on fibronectin mRNA level, mRNA stability, secretion and assembly in human fibroblasts. Journal of Cell Science. 108:1563-1571, 1995.

T. Daniels, L. Chou, J. Greenspan, D. Grady, W. Hauck, J. Green and V. Ernster: Reduction of Langerhans cells in smokeless tobacco-associated oral mucosal lesions. Journal of Oral Pathology and Medicine. 21;100-104, 1992.

L. Chou, L. Hansen and T. Daniels: Choristomas of the Oral Cavity. Oral Surgery, Oral Medicine and Oral Pathology. 72(11);584-593, 1991.

G. Ficarra, L. Chou and E. Panzoni: Granular odontogenic cyst (sialo-odontogenic cyst). International Journal of Oral and Maxillofacial Surgery. 19;331-333, 1990.

L. Chou and L. Hansen: Ganglioneuroma of the mandible. Oral Surgery, Oral Medicine and Oral Pathology. 68(2);201-205, 1989.

L. Kircos, M. Staninec and L. Chou: Rear earth filter for intraoral radiography: exposure reduction as a function of kVp with comparison of image quality. Journal of American Dental Association. 118(5);605-609, 1989.

L. Kircos, M. Staninec and L. Chou: Effective of developer temperature changes on the sensitometric properties of direct exposure and screen-film imaging systems. Dentomaxillofacial Radiology. 18(2);11-14, 1989.

L. Kircos, M. Staninec and L. Chou: Comparative evaluation of the sensitometric properties of screen-film systems and conventional dental receptors for intraoral radiography. Oral Surgery, Oral Medicine and Oral Pathology. 68(6);787-792, 1989.

L. Chou and L. Hansen: Oral manifestations of the AIDS-Up date. Journal of International Information of Stomatology. 2;68-72, 1988

L. Chou and L. Hansen: Acquired immunodeficiency syndrome (AIDS) and its oral manifestations. Journal of Stomatology. 6:57-60, 1986.

X. Wang, L. Chou, J. Liang and J. Ni: The location of the apical foramen of human teeth and its clinical significance. Journal of Stomatology. 6:212-215, 1985.

L. Chou: An epidemiological study of anodontia. Journal of International Information of Stomatology. 4:205-208, 1980.