Dana Graves Professor dgraves@bu.edu

education

DDS, Columbia University; CAGS, DMSc, Harvard University

research area

Cell Biology. Research interests include the origin of endodontic lesions that are exacerbated upon interference with the host’s ability to react to bacteria. Focus is also on aspects of the host response to bacterial infection, on the inflammatory response that leads to periodontal disease, and on the molecular mechanisms that lead to an altered host response in diabetics. Additional focus is on the role of cytokines in activating the response to periodontal and endodontic pathogens.

representative publications

Lu H, Kraut D, Gerstenfeld LC, Graves DT. Diabetes interferes with the bone formation by affecting the expression of transcription factors that regulate osteoblast differentiation. Endocrinology. 2003 Jan;144(1):346-52

Li L, Khansari A, Shapira L, Graves DT, Amar S. Contribution of interleukin-11 and prostaglandin(s) in lipopolysaccharide-induced bone resorption in vivo. Infect Immun. 2002 Jul;70(7):3915-22.

Graves DT, Nooh N, Gillen T, Davey M, Patel S, Cottrell D, and Amar S (2001). IL-1 Plays a Critical Role in Oral, but not Dermal, Wound Healing. J Immunol. 167:5316-20.

Graves DT, Oskoui M, Volenjnikova S, Naguib G, Cai S, Desta T, Kakouras A, Jiang Y (2001). Tumor Necrosis Factor Modulates Fibroblast Apoptosis, PMN Recruitment, and Osteoclast Formation in Response to P. Gingivalis Infection. J. Dent. Res. 80:1875-9.

Graves DT, Chen CP, Douville C, and Jiang Y (2000). IL-1 rather than TNF receptor signaling is critical in protecting the host from the severe consequences of a polymicrobe anaerobic infection. Inf. & Immun..68:4746-51.

Chih-Ping C, Hertzberg M, Jiang Y and Graves, D (1999) IL-1 and TNF receptor signaling is not required for bacteria-induced osteoclastogenesis and bone loss but is essential for protecting the host from a mixed anaerobic infection. Am. J. Pathol. 155:2145-52.

Valente AJ, Xie J, Abramova MA, Wenze UO, Abboud HE, and Graves DT (1998) A complex element regulates IFN-gamma-stimulated monocyte chemoattractant protein-1 gene transcription. J. Immunol. 161:3719-28.

Assuma R, Oates T, Cochran D, Amar S, and Graves DT.(1998). IL-1 And TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis. J. Immunol. 160:403-409.

recent grants

Bone-derived Cells Produce a Chemotactic Factor, 7/97 to 6/02, NIH-R01

Mechanisms of Periodontal Destruction, 9/99 to 7/03, NIH-R01

P. gingivalis-Host Interactions in Diabetes, 4/00 to 3/05, NIH-P01 project

Graves et al, Infect Immun, 68:4746-51, 2000.