Robert Gyurko Associate Professor gyurko@bu.edu

education

DDS, Semmelweis Medical University Budapest, Hungary; PhD, University of Florida (Gainesville)

representative publications

original reports

Gyurko, R., Kimura, B.,Kurian, P.,Crews, F.T.and Phillips, M.I. (1992) Angiotensin II receptor subtypes play opposite roles in regulating phosphatidylinositol hydrolysis in rat skin slices. Biochem.Biophys.Res.Comm. 186(1):285-292

Gyurko, R.,Wielbo, D. and Phillips, M.I. (1993) Antisense inhibition of AT-l receptor mRNA and angiotensinogen mRNA in the brain of spontaneously hypertensive rats reduces hypertension of neurogenic origin. Reg.Pept. 49:167-174

Phillips, M.I.,Wielbo, D.and Gyurko, R. (1994) Antisense inhibition of hypertension: A new strategy for renin-angiotensin candidate genes. Kidney Int. 46:1554-1556

Meng, H. ,Wielbo, D. ,Gyurko, R. and Phillips, M.I. (1994) Antisense inhibition of angiotensin type 1 receptor expression on drinking and vasopressin responses to central angiotensin in Sprague-Dawley and spontaneously hypertensive rats. Reg.Pept. 54:543-551

Wielbo, D., Sernia, C., Gyurko, R. and Phillips, M.I. (1995) Antisense inhibition of hypertension in the spontaneously hypertensive rat. Hypertension 25:314-319

Ambuhl, P., Gyurko, R. and Phillips, M.I. (1995) A decrease in angiotensin receptor binding in rat brain nuclei by antisense oligonucleotides to the angiotensin AT-1 receptor. Reg.Pept. 59:171-182

Gyurko, R., Tran, D. and Phillips, M.I. (1997) Time course if inhibition of hypertension by antisense oligonucleotides targeted to AT-1 angiotensin receptor mRNA in spontaneously hypertensive rats. Am. J. Hypertens. 10:56S-62S

Gyurko, R., Kuhlencordt, P., Fishman, M.C. and Huang, P.L. (2000) Modulation of mouse cardiac function in vivo by eNOS and ANP. Am. J. Physiol. 278:H971-H981

Kuhlencordt, P.J., Gyurko, R., Han, F. ,Scherrer-Crosbie, M., Aretz, T.H., Hajjar, R., Picard, M.H. and Huang, P. L. (2001) Accelerated atherosclerosis, aortic aneurysm formation and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice. Circulation 104(4):448-54.

Chen, J., Kuhlencordt, P., Astern, J., Gyurko, R., and Huang, P.L. (2001) Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apoE/eNOS double knockout mice. Circulation 1 04(20):2391-4.

Chen, J. Tung, C-H., Mahmood, U., Ntziachristos, V., Gyurko, R., Fishman, M.C., Huang, R. and Weissleder, R. (2002) In vivo imaging of proteolytic activity in active atherosclerosis Circulation 105(23):2766-71.

Gyurko, R., Leupen, S. and Huang, P.L. (2002) A novel nNOS knockout mouse lacking the heme binding domain exhibits infertility, pyloric stenosis and preserved brain morphology. Endocrinology. 143(7):2767-74.

Gyurko, R., Boustany, G., Huang, P.L., Kantarci, A., Van Dyke, T.E., Genco, C.A., and Gibson, F.C. (2003) Mice lacking inducible nitric oxide synthase demonstrate impaired killing of Porphyromonas gingivalis Infect. Immun. 71(9):4917-4924.

Gyurko, R., Shoji, H., Battaglino, R., Boustany, G., Gibson, F.C., Genco, C.A., Stashenko, P., Van Dyke, T.E. (2005) Inducible nitric oxide synthase mediates bone development and P. gingivalis-induced alveolar bone loss. Bone 36:472-9

review articles

Phillips, M.I. and Gyurko, R. (1995) In vivo applications of antisense oligonucleotides for peptide research. Reg.Pept. 59:131-141

Phillips, M.I. and Gyurko, R. (1997) Antisense oligonucleotides: new tools for physiology. News in Phys. Sci. 12:99-105

book chapters

Phillips, M.I.,Kimura, B. and Gyurko, R. (1994) Angiotensin receptor stimulation of Transforming Growth Factor-beta in rat skin and wound healing. In: Angiotensin receptors Ed: J.M.Saavedra and P.B.M.W.M.Timmermans. Plenum Press, New York pp.377-396

Phillips, M.I. and Gyurko, R. (1997) Antisense oligonucleotides targeted to the angiotensin system as a novel strategy to treat hypertension. In: Antisense oligonucleotides and antisense RNA as novel pharmacological and therapeutic agents. Ed.: Weiss, B. CRC Press, Boca Raton, FL pp.131-148.

Huang, P.L., Gyurko, R. and Zhang, L. (1999) Cardiovascular effects of nitric oxide: Lessons learned from endothelial nitric oxide synthase knockout mice. In: Endothelium, Nitric Oxide, and Atherosclerosis. Ed.: Panza, J.A. and Cannon, R.O. Futura Publishing Co, Inc, Armonk, NY pp. 37-48.

recent grant

“Nitric Oxide Defense Against Porphyromonas Gingivalis.” NIH/NIDCR. 01/01/03– 12/31/06. This is a Scholar Development and Faculty Transition Award, focusing on the study of the role of nitric oxide in the inflammatory response and bone resorption in response to P. gingivalis infection in mouse knockout models