faculty

Thomas Van Dyke Professor; Program Director, Postdoctoral Periodontology; Director, Clinical Research Center tvandyke@bu.edu

education

DDS, Case Western University; MS, CAGS, PhD, State University of New York at Buffalo

research goals

The long-range goals of the basic science investigations is to gain further knowledge of the structural and functional relationship of the inflammatory process by defining the complex interactions between phagocytic cells and their environment, particularly microorganisms. These interactions are important in the pathogenesis of many disease processes. The clinical research program is focused on the elucidation of factors inherent in the pathogenesis of periodontal diseases. The applied clinical research program is focused upon the clinical evaluation of products, procedures and diagnostics for the management of periodontal disease.

representative publications

Van Dyke TE, Serhan CN. Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases. J Dent Res 2003 82:82-90.

Kantarci A, Van Dyke TE. Neutrophil-mediated host response to Porphyromonas gingivalis. J Int Acad Periodontol. 2002 Oct;4(4):119-25. Review.

Oringer RJ, Van Dyke TE, Lessem J. The challenge of treating periodontal patients who smoke--the efficacy of Arestin. J Int Acad Periodontol. 2002 Jul;4(3):89-94.

Van Dyke TE, Offenbacher S, Braswell L, Lessem J. Enhancing the value of scaling and root-planing: Arestin clinical trial results. J Int Acad Periodontol. 2002 Jul;4(3):72-6.

Newman HN, Van Dyke TE. The relationship between oral infections and systemic disease.J Int Acad Periodontol. 2002 Jul;4(3):71.

Delima AJ, Sjodon BE, Tonetti MS, Bimstein E, Newman HN and Van Dyke TE (2001). Periodontal Disease in Children, Adolescents and Yong Adults. In: Periodontal and Gingival Health and Diseases; E Bimstein, HL Needleman, N Karimbux, TE Van Dyke (eds), Martin Dunitz.

Shibata K, Warbington ML, Gordon BJ, Kurihara H and Van Dyke T (2001). Nitric Oxide Synthase Activity in Neutrophils from Patients with Localized Juvenile Periodontitis. J. Periodontol, 72:1052-58.

Mickels N, McManus C, Massaro J, Friden P, Braman V, D’Agostino R, Oppenheim F, Warbington M, Dibart S and Van Dyke T (2001). Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis. J. Clin. Periodontol. 28(5):404-10.

Van Dyke TE. and Tohem Z (2000) Periodontal Diagnosis: Evaluation of current concepts and future needs. J. Int’l. Acad. Periodontol. 2: 71-79.

Shibata K, Warbington ML, Gordon BJ, Kurihara H and Van Dyke TE (2000) Defective calcium influx factor activity in neutrophils from patients with localized juvenile periodontitis. J. Periodontol. 71: 797-802.

Pouliot M, Clish CB, Petasis NA, Van Dyke TE and Serhan CN (2000) Lipoxin A (4) analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease. Biochem. 39(16):4761-8.

de Santana RB, Gusman HC and Van Dyke TE (1999) The response of human buccal maxillary furcation defects to combined regenerative techniques-two controlled clinical studies. J. Int. Acad. Periodontol. 1(3):69-77.

recent grants

“Boston Center for Clinical Trials Research”, 6/99 – 5/03, NIH T35 training grant

“Modulation of Molecular Pathogenesis in Systemic Disease”, 4/00 – 3/04, NIH Program Project grant

“Treatment of Periodontal Infections”, Boston Oral Health Clinical Resource Center, 8/00 – 7/02 NIH grant

“Molecular Mechanisms in Leukocyte-Mediated Tissue Injury”, 4/00 – 3/04, NIH Program Project grant

Pouliot et al, Biochemistry 39:4761-4768 2000.