
Photo: Neonatal acinar
cell
marker B1 ch 27,
2008
identifies acinar
cell
precursors early
in
the embryonic
development of the
mouse submandibular gland. Immunofluorescence
staining of the B1
protein
(green) at embryonic
day 14
(E14) is restricted to the outer
cell
layer of the
developing buds (E14,
20X, white solid
box; E14, 40X, block
arrow),
while the remaining
cells
marked by
filamentous actin
(F-actin, red) are negative (E14, unfilled
block arrows).
The B1 protein is
maintained in the outer
cell
layer at
later
stages of development (E15.5,
20X, block arrow). In the cytodifferentiated
SMG at
E18.5, acinar
cells
display prominent
B1 expression
(block
arrow), while the ducts
remain negative
(unfilled
arrow).
Contributed by Sheede
Khalil
and
Dr. Maria Kukuruzinska,
Boston University
Goldman
School of
Dental
Medicine
Department of Molecular
and
Cell Biology.
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